Hupertsiini A

Hupertsiini A
Tunnisteet
IUPAC-nimi	(1R,9R,13E)-1-amino-13-etylideeni-11-metyyli-6-atsatrisyklo[7.3.1.02,7]trideka-2(7),3,10-trien-5-oni
CAS-numero	102518-79-6
PubChem CID	854026
SMILES	CC=C1C2CC3=C(C1(CC(=C2)C)N)C=CC(=O)N3
Ominaisuudet
Molekyylikaava	C15H18N2O
Moolimassa	242,32 g/mol
	Infobox OK

Hupertsiini A on kiinalaisessa yrttilääketieteessä käytetystä Huperzia serrata -kasvista (ketunliekolaji) eristetty seskviterpeeneihin ja alkaloidieihin kuuluva yhdiste, jonka nootrooppisia vaikutuksia on tutkittu Kiinassa ihmisillä kehitettäessä lääkkeitä Alzheimerin tautiin^[1]. Sillä on muistia ja kognitiivisia toimintoja tehostavia vaikutuksia ainakin Alzheimerin tautia sairastavilla.^[2]

Hupertsiini A on voimakas reversiibeli asetyylikoliiniesteraasi-inhibiittori^[3]^[4] ja NMDA-antagonisti^[5]^[6]. Ainakin rotilla se lisää hermokasvutekijöiden eritystä tietyntyyppisissä hermosoluissa^[7].

Lähteet

↑ Pharmacology, biochemistry and behavior, 2003 Jun;75(3):675-86, The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease.
↑ Acta Pharmacologica Sinica, 1995 Sep;16(5):391-5, Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease.
↑ Journal of neuroscience research, 1989 Oct;24(2):276-85, Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat.
↑ Acta Pharmacologica Sinica, 1996 Nov;17(6):481-4, Huperzine A (shuangyiping): a promising drug for Alzheimer's disease.
↑ Neuroscience, 2001;105(3):663-9, Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.
↑ Acta Pharmacologica Sinica, 1999 Jan;20(1):31-5 Modulation of NMDA receptor by huperzine A in rat cerebral cortex.
↑ Acta Pharmacologica Sinica, 2005 Jun;26(6):673-8, Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells.

Aiheesta muualla

ChemBlink: (-)-Huperzine A (englanniksi)

Tämä lääketieteeseen liittyvä artikkeli on tynkä. Voit auttaa Wikipediaa laajentamalla artikkelia.

[1] Pharmacology, biochemistry and behavior, 2003 Jun;75(3):675-86, The psychopharmacology of huperzine A: an alkaloid with cognitive enhancing and neuroprotective properties of interest in the treatment of Alzheimer's disease.

[2] Acta Pharmacologica Sinica, 1995 Sep;16(5):391-5, Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease.

[3] Journal of neuroscience research, 1989 Oct;24(2):276-85, Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat.

[4] Acta Pharmacologica Sinica, 1996 Nov;17(6):481-4, Huperzine A (shuangyiping): a promising drug for Alzheimer's disease.

[5] Neuroscience, 2001;105(3):663-9, Huperzine A, a nootropic alkaloid, inhibits N-methyl-D-aspartate-induced current in rat dissociated hippocampal neurons.

[6] Acta Pharmacologica Sinica, 1999 Jan;20(1):31-5 Modulation of NMDA receptor by huperzine A in rat cerebral cortex.

[7] Acta Pharmacologica Sinica, 2005 Jun;26(6):673-8, Effects of huperzine A on secretion of nerve growth factor in cultured rat cortical astrocytes and neurite outgrowth in rat PC12 cells.

[1]

[2]

[3]

[4]

[5]

[6]

[7]