Ero sivun ”Karnosiini” versioiden välillä
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p Botti lisäsi: ru:Карнозин |
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Rivi 51:
== Karnosiini koeputkikokeissa ==
Karnosiini ehkäisee [[triglyseridit|triglyseridien]] ja kolesterolin hapettumista sekä [[glykaatio|glykaatiota]] koeputkikokeissa. <ref> Lee YT, Hsu CC, Lin MH, et al. Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation. European Journal of Pharmacology 2005;513(1–2):145–150</ref><ref name="lop">Rashid I, van Reyk DM, Davies MJ. Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro. FEBS Lett. 2007;581(5):1067–1070</ref><ref>Decker EA, Ivanov V, Zhu BZ, Frei B. Inhibition of low-density lipoprotein oxidation by carnosine histidine. J Agric Food Chem. 2001;49(1):511–516</ref> <ref
Karnosiini saattaa suojata viljeltyjä soluja hapettumistressiltä, ja proteiinejä glykaatiolta.<ref>Calabrese V, Cornelius C, Mancuso C, et al. Cellular Stress Response: A novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity. Neurochem Res. 2008 Jul 16. [http://www.springerlink.com/content/w733k182190rj431/Epub ahead of print]</ref><ref>Sonneborn JS. Hormetic triggers for intervention in aging, disease and trauma. American Journal of Pharmacology and Toxicology 3 (1): 1-10, 2008[http://www.scipub.org/fulltext/AJPT/AJPT311-10.pdf[Full Free text]</ref> Karnosiini hidastaa ihmisen viljeltyjen sidekudossolujen ([[fibroblasti]]en) vanhenemista ja pidentää niiden elinikää huomattavasti.<ref>Kantha SS, Wada S, Tanaka H, et al. Carnosine sustains the retention of cell morphology in continuous fibroblast culture subjected to nutritional insult. Biochem Biophys Res Commun 1996; 223(2):278–282</ref><ref> McFarland GA ,Holliday R. Further evidence for the rejuvenating effects of the dipeptide I L--carnosine on cultured human diploid fibroblast. Exp Gerontol 1999 34(l):35–45</ref><ref>Hipkiss AR. Biosynthesis, Release, and Uptake of Carnosine in Primary Cultures. Review. Biochemistry (Mosc) 2000 c;65:7</ref>. Vaikutus perustunee kromosomien DNA:n [[telomeeri]]en vaurioiden ehkäisyyn.<ref>Shao L, Li QH, Tan Z. l-Carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts. Biochem Biophys Res Commun. 2004 Nov 12;324(2):931–936</ref>
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